When it comes to making ISO adjustments...
Here is a shot taken (at the event I mentioned the other day) shot at 12800iso (of course some NR has been added):
And here's a 100% crop:
Some would say... "oh no, NOISE!" (probably landscape photographers
)... However you can see, expose it right and add a little NR and 12800 (on a 1Dx tee hee) can be fine. Also, you need to look at it as a whole and for what purpose it is being shot AND the subject (as mentioned a landscaper couldn't handle this much noise, but for event photography it's fine). 
you'll need to get friendly with higher ISO 
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