I use a Mountainsmith Tanuck 40 and I can HIGHLY recommend it if you're feeling short on storage space. It'd also rugged, probably the most adventure designed bag I've ever seen. The base is waterproof, the rest of the pack is Cordura nylon and the zippers are heavy duty. I cant say enough good about this pack honestly. It's a true adventure pack. It uses gear cubes of large and medium size. Top access can expand to accommodate additional gear as well.
If you're interested in something more bespoke, check out Atlas packs. They have 3 frame sizes to choose from. If you're a human of impressive size, they have a frame for you. They use an integrated storage area that can be expanded and shrunk a bit based on your gear needs.
Both are excellent pack and feature excellent comfort and ergonomics. Shimoda is also a decent choice although some find the lack of numerous exterior pockets a bother.